UnitedHealth can reach about $450 by year-end as rising inflation pushes investors toward defensives with pricing power. If its medical loss ratio comes in as expected for the full year, confidence may be fully restored and the stock may regain its premium valuation. Management guides for $18.25 EPS this year; at its 10-year average P/E of 24, that implies about $438, and any EPS beat takes it above $450. The stock is now nearly at the earlier $400 call. x.comÂ