Biotech2k
Biotech Investor, AI-Driven Drug Discovery
Tempus AI is cheap for its level of growth in the low $40s, contrary to an AI-generated analysis calling it fully valued. That Google AI Studio analysis rates the business elite: 33% year-on-year quarterly revenue growth, faster growth in high-margin data and services, a large multimodal clinical and genomic data library feeding a flywheel, and a path to adjusted EBITDA profitability within 12 months. It flags cash burn, dilution, FDA lab-test rules and competition as risks. x.comÂ
Tempus AI has a data moat no one has replicated: a multimodal, patient-linked genomic, clinical and imaging dataset at scale. It holds over 8 million imaging files, 1.5 million matched clinical and molecular profiles and 4.5 million sequencing samples, which drug companies leaning on AI increasingly need. It is expanding from oncology into cardiology, neuropsychiatry and radiology. Revenue grows 25% and gross margin rose from 32% in 2021 to 64%, though last quarter's profit was a one-time item. … Show more
Tempus AI's thesis remains intact after objectively strong earnings and a guidance raise. It looks less threatened by Anthropic than other software names because its datasets form its moat, for now. Software multiples remain a big question, and these stocks are struggling to catch a break, but the technical setup still looks good despite the pullback. x.comÂ
Tempus AI is a short idea because the stock is being pumped on recent FDA clearances for its EKG-AI tools, while the revenue from them is far off and may never materialize. x.comÂ
Tempus AI's acquisition of Personalis gives it the technology platform behind Moderna's and Merck's recent cancer-vaccine advances. x.comÂ
Tempus AI's diagnostics-to-data-to-AI flywheel makes its roughly 7.2x forward sales interesting, about half Natera's and Guardant's 16x, though both grow faster. Q2 revenue rose 22% to $382.5M, Data Licensing & Modeling grew 36%, and 2026 guidance is about $1.6B of revenue and $65M of adjusted EBITDA. As a ~25% growth diagnostics company, ~7x may be reasonable; if growth reaccelerates toward 30%+, Data + Applications grows much larger and margins expand, the valuation could look very different. … Show more
Tempus AI is a second- or third-tier genomic lab whose AI story is marketing mumbo jumbo, and its management team are promoters. x.comÂ
Tempus AI's $1.5B all-stock acquisition of Personalis is smart long-term positioning despite the dilution-driven dip. Owning Personalis's NeXT Personal MRD technology outright lets Tempus pair liquid-biopsy recurrence testing, one of oncology's fastest-growing areas, with its multimodal dataset and AI at scale. That extends Tempus from diagnostics into high-margin longitudinal monitoring and could strengthen its moat, though execution will decide it. x.comÂ
Tempus AI and Caris Life Sciences both represent good value in AI-driven biopharma diagnostics. Tempus has some advantages, but with Caris running faster lately the two have become closer; at about $55 for Tempus and $16 for Caris, Caris was the preference, while the choice between them today is less clear. x.comÂ
Tempus AI may go lower near term because of valuation, leadership reputation and insider selling, despite an amazing business. With about 25% growth expected and profitability uncertain, it is not obviously cheap. Glassdoor reviews matter in medicine's high-trust setting, and ongoing insider sales echo founder patterns that ended badly. The data piece, about 5% of market cap, can earn a high multiple, so the stock looks reasonably priced if adoption continues. x.comÂ
Tempus AI has quietly built a data moat the market hasn't figured out. It holds 45 million de-identified patient records and 500+ petabytes of clinical data, partners with AstraZeneca, GSK and Merck, and has FDA approval for its xT CDx test. With 20% short interest, a bottom is forming at $42-46, and a buy signal triggered at $55.87. x.comÂ