Zenas BioPharma's clinical data do not meet the best-in-class or first-in-class standard after closer review. It no longer fits the investment criteria despite the earlier view of its late-stage potential and cheap valuation. x.com  x.com 

Mirum's small indications cap its upside, while Q4 Hep D phase 3 data must be good and its PSC filing on phase 2 data risks rejection after the FDA asked for phase 3. Those risks are priced in only below $80, where Mirum is worth holding and building. Above $95 it is an easy sell until the risks play out; $99 is a stated sale level if the stock gets too expensive. x.com  x.com 

Ionis is best avoided because major Phase 3 trials still hang over it, making it hard to size a meaningful position while controlling risk. Biotechs can drop 10-30% overnight on a negative read-through from another company's similar drug, with no chance to react, and a 1-2% position is mostly a waste of time. Biotech names are worth owning only once profitable, generating real cash and free of major Phase 3 risk. x.com 

Apnimed's IPO looks unattractive because clinical-stage biotech IPOs tend to face future dilution and uncertain multi-year outcomes. Its sleep apnea market may also be shrinking, since GLP-1 weight-loss drugs from Novo Nordisk and Eli Lilly already help many cases, at least for patients who can afford either type of medicine. x.com 

Viking Therapeutics now has enough cash to finish its phase 3 trials, so it can hold out for a home-run acquisition offer, likely nothing below $200 a share after its positive maintenance trial. The offering added $547.8M, lifting cash to about $1B, enough for roughly 24 months at a bit over $40M of monthly burn, though phase 3 may burn faster, and possibly close to the NDA stage. Dilution of 9% from stock and 5% from converts will be worth it. x.com  x.com 

AI drug-discovery picks and shovels such as Ginkgo Bioworks, 10x Genomics, Twist Bioscience and Grail are priced on a fantasy, and secondary offerings are coming. The bet that AI will solve cancers and rare diseases within months ignores how drug discovery, regulation and trial enrollment actually work. Unlike the semiconductor comparison, these businesses have not inflected, mostly burn cash, trade at 20-30x sales and need equity to fund themselves. Buyers here become their liquidity. x.com  … Show more

Absci is a binary-risk biotech, either a multibagger or a total failure, and less tempting than AbCellera's AI antibody platform. Its losses are large and persistent, and as cash dwindles more dilution should follow, with the share count still rising. Unlike AbCellera, it lacks solid partner programs and a robust build-out. The stock is stuck between $2.50 and $6.50: bad trial data could send it back to the bottom, while positive data or a new partnership could break it out. x.com 

Prime Medicine will trade on hype and fumes until it shows positive clinical data, likely not before sometime in 2027, because it is still a Phase 1 company. Its technology reads as almost too good to be true, but genomics has many promising players and it is hard to know now who will win, which favors a broad genomics ETF over a single name. x.com 

Small- and mid-cap biotech looks like one of healthcare's more asymmetric setups after a four-year bear market, as AI speeds drug discovery and Big Pharma faces a patent cliff. Over $300B of pharma revenue goes off patent in the next few years, M&A is already ramping hard as pharma hunts for assets, and many small and mid-cap names still trade at reasonable valuations, making them potential takeover targets. x.com